Qhov zoo ntawm Capsule

Nyob rau hauv 1500 BC, thawj capsule tau yug los hauv Egypt.

Xyoo 1730, cov kws muag tshuaj hauv Vienna pib ua tshuaj ntsiav los ntawm cov hmoov txhuv nplej siab.

Nyob rau hauv 1834, capsule manufacturing technology tau patented hauv Paris.

Xyoo 1846, ob-section hard capsule manufacturing technology tau txais hauv Fabkis Patents.

Nyob rau hauv 1848, ob-thooj capsules tau tawm. Txij thaum ntawd los, Empty capsule shells nkag mus rau hauv lub ntiaj teb kev kho mob thiab tau los ua cov ntim tshuaj.

Xyoo 1874, kev tsim khoom lag luam ntawm cov tshuaj ntsiav nyuaj (Hubel) tau pib hauv Detroit, thiab ntau yam qauv tau qhia tib lub sijhawm.

Xyoo 1888, Parke-Davis tau txais patent rau kev tsim cov tshuaj ntsiav nyuaj hauv Detroit (JB Russell)

Xyoo 1931, Parke-Davis 'capsule manufacturing ceev mus txog 10,000 capsules ib teev (A. Colton)

Raws li cov khoom ntim tshuaj zoo tagnrho, Empty hard capsule shells yog siv dav hauv kev npaj tshuaj. Lawv feem ntau faib rau hauv cov hmoov, kua, semi-solid, tshuaj pleev, ntsiav tshuaj thiab lwm yam kev npaj. Lawv tuaj yeem ua tau sai, ntseeg tau thiab nyab xeeb decomposed. Lawv muaj qhov zoo hauv qab no:

1) Zoo nkauj luster thiab yooj yim rau nqos.

2) Masking nyhuv: Nws tuaj yeem npog qhov tsis xis nyob iab thiab tsw ntawm cov tshuaj, thiab tiv thaiv thiab ua kom cov ntsiab lus tsis ruaj khov.

3) Cov tshuaj bioavailability siab: Cov tshuaj ntsiav tsis tas yuav muaj cov nplaum thiab siab thaum npaj xws li cov ntsiav tshuaj thiab cov tshuaj, yog li lawv tawg sai sai thiab nqus tau zoo hauv plab thiab hnyuv.

4) Kev tiv thaiv zoo dua ntawm cov khoom siv tshuaj ntsuab: Yog tias tsis muaj qhov kub thiab txias siab los ntawm cov ntsiav tshuaj xovxwm, lub xeev ntawm cov khoom siv tshuaj ntsuab hauv cov tshuaj ntsiav tuaj yeem khaws cia.

5) Nws tuaj yeem ua rau hauv kev npaj tso tawm thiab kev npaj sib xyaw:

Cov tshuaj tuaj yeem tso tawm hauv lub sijhawm thiab qhov chaw (enteric-coated, pulsed thiab lwm cov tshuaj tso tawm). Yog tias cov tshuaj tau ua thawj zaug rau hauv cov khoom, thiab tom qab ntawd gelatin raw cov ntaub ntawv thiab cov khoom siv nrog ntau qhov kev tso tawm, cov nyhuv ntawm lub sijhawm thiab qhov tso tawm tuaj yeem ua tiav. Yog li ntawd, cov tshuaj ntsiav yog cov ntaub ntawv zoo tshaj plaws rau kev tsim cov tshuaj tiv thaiv-tso tawm thiab kev npaj ua ke.

6) Cov txheej txheem tshuaj thiab kev npaj yog yooj yim, yooj yim rau industrialization thiab automation Production.